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    There are 3 cases available...

    Go to the top of the page   ID: 20090731100700 Original case in german  More links about this topic on Pubmed (PubMed Reader)
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    Discussion
     
    Osteogenesis imperfecta (fetal)
    ( This case will be soon translated into the english language. )
    THaufe , Radiologie , SKH Dresden-Neustadt. Osteogenesis imperfecta (fetal). PedRad [serial online] vol 9, no. 7.
    URL: www.PedRad.info/?search=20090731100700


     
     Pediatric Radiology CasesImages to this case: There are X-Ray-images available for this case. [ X-Ray ] View all modalities [ All ]   
     Pediatric Radiology CasesAuthor/s:

    T.Haufe, Radiologie, SKH Dresden-Neustadt  

     
     Pediatric Radiology CasesEmail Address:

    Viewable for logged on visitors (Log on)  

     
     Pediatric Radiology CasesAge:

    0 Preterm  

     
     Pediatric Radiology CasesGender:

    Male  

     
     Pediatric Radiology CasesRegion-Organ:

    Generalized diseases  

     
     Pediatric Radiology CasesMost likely etiology:

    congenital  

     
     Pediatric Radiology CasesHistory:

    Es erfolgte ein induzierter Abort in der 20. SSW wegen sonographischem Verdacht auf eine letale fetale Skelettdysplasie.
    Es sind keine familiären Erkrankungen bekannt.
    ein gesundes Geschwisterkind,  

     
     Pediatric Radiology CasesPathomorphology or Pathophysiology of this disease :

    Überwiegend autosomal dominanter Erbgang, Genmutation im Kollagen1- oder 2-Gen mit verminderter Synthese und Strukturveränderungen der Kollagenfasern, variable klinische Ausprägung (vier Typen),
    typisch ist eine erhöhte Knochenbrüchigkeit und blaue Skleren,  

     
     Pediatric Radiology CasesRadiological findings:


    X-Ray 1 <- view X-Ray 1

    Röntgen 1: multiple mehrzeitige Rippenfrakturen mit Deformierungen und Kallusbildung, teilweise Rippenverkürzung




    X-Ray 2 <- view X-Ray 2

    Röntgen 2: für das Gestationsalter zu geringe Mineralisation des Schädels




    X-Ray 3 <- view X-Ray 3

    Röntgen 3: Deformierung,Verkürzung und Auftreibung der unteren Extremitäten durch multiple mehrzeitige Frakturen, geringe Mineralisation des Beckenskelettes,




    X-Ray 4 <- view X-Ray 4

    Röntgen 4: Armdeformierung durch multiple mehrzeitige Frakturen, Verkürzung und Verdickung der langen Röhrenknochen, inhomogene Knochenstruktur,


     

     
     Pediatric Radiology CasesDiagnosis confirmation:

    Total constellation (Consens)  

     
     Pediatric Radiology CasesWhich DD would be also possible with the radiological findings:

    N/A  

     
     Pediatric Radiology CasesCourse / Prognosis / Frequency / Other :

    Im vorliegenden Fall wurde nach genetischer Beratung in der 20.SSW wegen schlechter Prognose ein induzierter Abort durchgeführt.
    Postmortal wurden Röntgenaufnahmen und ein Ganzkörper-CT angefertigt.
    Die postmortale klinische und radiologische Diagnose wurde durch ein genetisches Gutachten bestätigt.
    Insgesamt ist die Prognose abhängig vom Typ oder Subtyp.
    Bei im vorliegendem Fall wohl vorliegendem Typ II-B ist die Prognose undünstig.  

     
     Pediatric Radiology CasesComments of the author about the case:

    Lt. des genetischen Gutachtens (Dr. M. Linné, Dresden) liegt in diesem Fall eine Neumutation vor.
    Das Wiederholungsrisiko wurde als gering eingeschätzt.  

     
     Pediatric Radiology CasesFirst description / History:

    N/A  

     
     Pediatric Radiology CasesLiterature:

    1. Medline: Medline
    Schumacher, Seaver, Spranger
    Fetal Radiology, A Diagnostic Atlas
    Springer Berlin, Heidelberg, New York 2004
     

     
     Pediatric Radiology CasesKeywords:

    Osteogenesis imperfecta, intrauterine Frakturen, Glasknochenkrankheit  

     
     Pediatric Radiology Cases Cite this article:

    THaufe , Radiologie , SKH Dresden-Neustadt. Osteogenesis imperfecta (fetal). PedRad [serial online] vol 9, no. 7.
    URL: www.PedRad.info/?search=20090731100700  

     
     Pediatric Radiology Cases Read similar articles: Glasknochenkrankheit&type=1-17">corresponding keywords
    in the same field: Generalized diseases
    or in the region: Generalized diseases
    or in the tissue/organ:
    or with the etiology: congenital
     
     Pediatric Radiology CasesImages to this case: There are X-Ray-images available for this case. [ X-Ray ] View all modalities [ All ]   
     
    Osteogenesis imperfecta (fetal)
    ( This case will be soon translated into the english language. )
    THaufe , Radiologie , SKH Dresden-Neustadt. Osteogenesis imperfecta (fetal). PedRad [serial online] vol 9, no. 7.
    URL: www.PedRad.info/?search=20090731100700


     

    Search similar cases in:
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    Osteogenesis imperfecta (fetal)
    Other cases by these authors:

    Search T.Haufe in Medline T.Haufe (1)   
    • 1:
    Search Radiologie in Medline Radiologie (10)   
    Search SKH Dresden-Neustadt in Medline SKH Dresden-Neustadt (1)   
    • 1:

    Osteogenesis imperfecta (fetal)  
     
    Osteogenesis imperfecta (fetal)
    ( This case will be soon translated into the english language. )
    THaufe , Radiologie , SKH Dresden-Neustadt. Osteogenesis imperfecta (fetal). PedRad [serial online] vol 9, no. 7.
    URL: www.PedRad.info/?search=20090731100700


     
     
    Osteogenesis imperfecta (fetal)
    ( This case will be soon translated into the english language. )
    THaufe , Radiologie , SKH Dresden-Neustadt. Osteogenesis imperfecta (fetal). PedRad [serial online] vol 9, no. 7.
    URL: www.PedRad.info/?search=20090731100700


     

    Medical Dictionary
    Search in medical dictionary for
    Or type in a keyword
    ( Provided by The On-Line Medical Dictionary )




    1 = less interesting)
     
    Osteogenesis imperfecta (fetal)
    ( This case will be soon translated into the english language. )
    THaufe , Radiologie , SKH Dresden-Neustadt. Osteogenesis imperfecta (fetal). PedRad [serial online] vol 9, no. 7.
    URL: www.PedRad.info/?search=20090731100700


     


    Go to the top of the page   ID: 20030222173416 Original case in english  More links about this topic on Pubmed (PubMed Reader)
    Add this case to your RSS feeder: Subscribe to RSS feed Add to Yahoo Add to Google Add to AOL Add to Furl Subscribe to Feed Burner feed

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    Discussion
     
    Testicular microlithiasis
    ( This case will be soon translated into the english language. )
    Dirk Schaper, V Hofmann. Testicular microlithiasis. PedRad [serial online] vol 3, no. 2.
    URL: www.PedRad.info/?search=20030222173416


     
     Pediatric Radiology CasesImages to this case: There are Ultrasound-images available for this case. [ Ultrasound ] View all modalities [ All ]   
     Pediatric Radiology CasesAuthor/s:

    Dirk Schaper, V. Hofmann (Halle/S.)  

     
     Pediatric Radiology CasesEmail Address:

    Viewable for logged on visitors (Log on)  

     
     Pediatric Radiology CasesAge:

    19 Months  

     
     Pediatric Radiology CasesGender:

    Male  

     
     Pediatric Radiology CasesRegion-Organ:

    N/A  

     
     Pediatric Radiology CasesMost likely etiology:

    N/A  

     
     Pediatric Radiology CasesHistory:

    1 7/12 year-old boy, findings after hydrocele resection (at 2.5 months) because of monstrous hydrocele on both sides. Ultrasound due to reoccuring hydrocele on the right side and testicular raising on the left.  

     
     Pediatric Radiology CasesPathomorphology or Pathophysiology of this disease :

    Hypothesis: testicular microlithiasis as a result of a multifocal sartoli-cell dysfunction.  

     
     Pediatric Radiology CasesRadiological findings:


    X-Ray 1 <- view X-Ray 1

    Röntgen 1: multiple mehrzeitige Rippenfrakturen mit Deformierungen und Kallusbildung, teilweise Rippenverkürzung




    X-Ray 2 <- view X-Ray 2

    Röntgen 2: für das Gestationsalter zu geringe Mineralisation des Schädels




    X-Ray 3 <- view X-Ray 3

    Röntgen 3: Deformierung,Verkürzung und Auftreibung der unteren Extremitäten durch multiple mehrzeitige Frakturen, geringe Mineralisation des Beckenskelettes,




    X-Ray 4 <- view X-Ray 4

    Röntgen 4: Armdeformierung durch multiple mehrzeitige Frakturen, Verkürzung und Verdickung der langen Röhrenknochen, inhomogene Knochenstruktur,



    Ultrasound 1 <- view Ultrasound 1

    Ultrasound 1: multiple echogenic, in both testes diffusely distributed focuses without acoustic shadows. Circa 1 mm large focus (like snow flurries). Colored doppler sonography was inconspicuous.

     

     
     Pediatric Radiology CasesDiagnosis confirmation:

    N/A  

     
     Pediatric Radiology CasesWhich DD would be also possible with the radiological findings:

    N/A  

     
     Pediatric Radiology CasesCourse / Prognosis / Frequency / Other :

    Testicular microlithiasis (TM) is a rare, most bilateral finding in ultrasound in boys and men. The increasing frequency in sonographic examinations of the testicles and the better ultrasound machines allow the diagnosis to be made more often. The incidence is given at 1.7 - 1.9%.
    Noticeable is the combination of TM with other illnesses of the male genitalia (hydrocele, varicocele, epididymitis, testicular atrophy and germ cell tumor). A link between TM and tumor development cannot be surely proven at this point. Yearly sonographic examinations and follow-up examinations of the tumor factors are recommended. A biopsy can be made in cases with a focal parenchymal lesion.  

     
     Pediatric Radiology CasesComments of the author about the case:

    N/A  

     
     Pediatric Radiology CasesFirst description / History:

    Priebe CJ, Garret R (1970) Testicular calcifications in a 4-year-old boy. Pediatrics 46: 785-788  

     
     Pediatric Radiology CasesLiterature:

    2. Medline: Medline
    DellÀcqua A, Toma P, Oddone M, Ciccone MA, Marsili E, Derchi LE
    Testicular microlithiasis: US findings in six pediatric cases and literature review.
    Eur Radiol 1999;9(5):940-4

    3. Medline: Medline
    Otite U, Webb JA, Oliver RT, Badenoch DF, Nargund VH.
    Testicular microlithiasis: is it a benign condition with malignant potential?
    Eur Urol 2001 Nov;40(5):538-42

    4. Medline: Medline
    Furness PD 3rd, Husmann DA, Brock JW 3rd, Steinhardt GF, Bukowski TP, Freedman AL, Silver RI, Cheng EY.
    Multi-institutional study of testicular microlithiasis in childhood: a benign or premalignant condition?
    J Urol 1998 Sep;160(3 Pt 2):1151-4
     

     
     Pediatric Radiology CasesKeywords:

    Testes, microlithiasis, Testicular microlithiasis, hydrocele resection, sartoli cell dysfunction  

     
     Pediatric Radiology Cases Cite this article:

    Dirk Schaper, V Hofmann. Testicular microlithiasis. PedRad [serial online] vol 3, no. 2.
    URL: www.PedRad.info/?search=20030222173416  

     
     Pediatric Radiology Cases Read similar articles: sartoli cell dysfunction&type=1-17">corresponding keywords
    in the same field:
    or in the region:
    or in the tissue/organ:
    or with the etiology:
     
     Pediatric Radiology CasesImages to this case: There are Ultrasound-images available for this case. [ Ultrasound ] View all modalities [ All ]   
     
    Testicular microlithiasis
    ( This case will be soon translated into the english language. )
    Dirk Schaper, V Hofmann. Testicular microlithiasis. PedRad [serial online] vol 3, no. 2.
    URL: www.PedRad.info/?search=20030222173416


     

    Search similar cases in:
    More links about this topic on Pubmed  More links about this topic on Yahoo  More links about this topic on Altavista  More links about this topic on MSN  More links about this topic on Google  More links about this topic on Fireball

    Peer-reviewed Radiology Search



    Testicular microlithiasis
    Other cases by these authors:

    Search T.Haufe in Medline T.Haufe (1)   
    • 1:
    Search Radiologie in Medline Radiologie (10)   
    Search SKH Dresden-Neustadt in Medline SKH Dresden-Neustadt (1)   
    • 1:
    Search Dirk Schaper in Medline Dirk Schaper (59)   
    Search V. Hofmann in Medline V. Hofmann (17)   

    Testicular microlithiasis  
     
    Testicular microlithiasis
    ( This case will be soon translated into the english language. )
    Dirk Schaper, V Hofmann. Testicular microlithiasis. PedRad [serial online] vol 3, no. 2.
    URL: www.PedRad.info/?search=20030222173416


     

    Which diagnosis have other collegues guessed?


    • Testicular microlithiasis
      Votes: 17 (60 %)


    • Orchitis
      Votes: 3 (10 %)


    • Leukemic testicular infestation
      Votes: 3 (10 %)


    • Disseminated Sartoli-cell tumor.
      Votes: 5 (17 %)



        Total answers: 28

     
    Testicular microlithiasis
    ( This case will be soon translated into the english language. )
    Dirk Schaper, V Hofmann. Testicular microlithiasis. PedRad [serial online] vol 3, no. 2.
    URL: www.PedRad.info/?search=20030222173416


     

    Medical Dictionary
    Search in medical dictionary for
    Or type in a keyword
    ( Provided by The On-Line Medical Dictionary )




    1 = less interesting)
     
    Testicular microlithiasis
    ( This case will be soon translated into the english language. )
    Dirk Schaper, V Hofmann. Testicular microlithiasis. PedRad [serial online] vol 3, no. 2.
    URL: www.PedRad.info/?search=20030222173416


     


    Go to the top of the page   ID: 20020815173954 Original case in english  More links about this topic on Pubmed (PubMed Reader)
    Add this case to your RSS feeder: Subscribe to RSS feed Add to Yahoo Add to Google Add to AOL Add to Furl Subscribe to Feed Burner feed

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    Discussion
     
    Fibrous cortical defect
    ( This case will be soon translated into the english language. )
    H Frimmel. Fibrous cortical defect. PedRad [serial online] vol 2, no. 8.
    URL: www.PedRad.info/?search=20020815173954


     
     Pediatric Radiology CasesImages to this case: There are X-Ray-images available for this case. [ X-Ray ] There are MRI-images available for this case. [ MRI ] View all modalities [ All ]   
     Pediatric Radiology CasesAuthor/s:

    H. Frimmel (Halle)  

     
     Pediatric Radiology CasesEmail Address:

    Viewable for logged on visitors (Log on)  

     
     Pediatric Radiology CasesAge:

    14 Years  

     
     Pediatric Radiology CasesGender:

    Female  

     
     Pediatric Radiology CasesRegion-Organ:

    N/A  

     
     Pediatric Radiology CasesMost likely etiology:

    N/A  

     
     Pediatric Radiology CasesHistory:

    14 year-old girl. Findings following a fibular fracture of the right talocrural joint in 01/2002. Thereby a chance finding of a "cystic finding" in the right distal tibia. Scintigraphy in 03/2002: no increased uptake, only slight photopenic area. Follow-up: Scintigraphy in 07/2002: marginally increased bone metabolism, possible tumor, therefore now sent to us for an MRI.  

     
     Pediatric Radiology CasesPathomorphology or Pathophysiology of this disease :

    Synonym: fibrous metaphyseal defect.
    Developmental disturbance in the metaphyseal region of the long bones, to 90% in the lower extremity.
    Defect with fibrous connective tissue with connection to the overlying periosteum.
    Classical "tumor-like" lesion.
    Is, when spanned over 4 cm, categorized as a "Non-ossifying fibroma"  

     
     Pediatric Radiology CasesRadiological findings:


    X-Ray 1 <- view X-Ray 1

    Röntgen 1: multiple mehrzeitige Rippenfrakturen mit Deformierungen und Kallusbildung, teilweise Rippenverkürzung




    X-Ray 2 <- view X-Ray 2

    Röntgen 2: für das Gestationsalter zu geringe Mineralisation des Schädels




    X-Ray 3 <- view X-Ray 3

    Röntgen 3: Deformierung,Verkürzung und Auftreibung der unteren Extremitäten durch multiple mehrzeitige Frakturen, geringe Mineralisation des Beckenskelettes,




    X-Ray 4 <- view X-Ray 4

    Röntgen 4: Armdeformierung durch multiple mehrzeitige Frakturen, Verkürzung und Verdickung der langen Röhrenknochen, inhomogene Knochenstruktur,



    Ultrasound 1 <- view Ultrasound 1

    Ultrasound 1: multiple echogenic, in both testes diffusely distributed focuses without acoustic shadows. Circa 1 mm large focus (like snow flurries). Colored doppler sonography was inconspicuous.


    X-Ray 1 <- view X-Ray 1

    X-ray 1: Sclerosed edges, cystic-looking defect in the corticalis.












    MRI 1 <- view MRI 1

    MRI 1: coronal T2-weighted image with fat saturation: Centrally, the mass is very low in signals without circumscribing edema. (Other findings: edema in the distal fibula following fracture)












    MRI 2 <- view MRI 2

    MRI 2: transversal T2-weighted image with fat saturation: In the corticalis of the tibia, there is a mass very low in signals without circumscribing edema.






    MRI 3 <- view MRI 3

    MRI 3: T1-weighted image, transversal: Excentric-lying lesion in the distal metaphysis of the right tibia, expansion: 3 cm, well-demarcated.






    MRI 4 <- view MRI 4

    MRI 4: T1-weighted image, transversal, with fat saturation after contrast: Excentric-lying lesion in the distal metaphysis of the right tibia, expansion: 3 cm, well-demarcated. No contrast uptake, some, discrete contrast uptake on the edges.



     

     
     Pediatric Radiology CasesDiagnosis confirmation:

    N/A  

     
     Pediatric Radiology CasesWhich DD would be also possible with the radiological findings:

    In this case, no further diagnostic tests were needed after x-ray.

    After stating the suspicion of a tumor after scintigraphy, an MRI was needed.

    In general, the MRI does not give us further information about fibrous cortical defects that would help us in the diagnosis. In this case, the signal weakness of the fibrous material lead us to our goal.

    In very large non-ossifying fibromas, the differential diagnosis could be juvenile or aneurysmatic bone cyst (proof of fluid in MRI).

    Benign fibrous histiocytoma (age of the patient, pain).  

     
     Pediatric Radiology CasesCourse / Prognosis / Frequency / Other :

    No symptoms. Often x-ray chance findings in the 1st and 2nd decade of life.
    Very rarely spontaneous fractures.
    Usually disappears in further bone development by the age of 18.  

     
     Pediatric Radiology CasesComments of the author about the case:

    Overall, conventional x-ray with the "classic findings":]
    - sharply bordered, solitary radiolucency, parallel to the corticalis, located excentric in the metaphysis of the long bones (mostly lower extremity). It is divided from the healthy bone by a sclerosis band. In conjunction with the patient's history and clinical signs (age, missing symptoms), it is usually enough to make the diagnosis.

    The MRI was performed due to the not quite clear findings in the scintigraphy.  

     
     Pediatric Radiology CasesFirst description / History:

    N/A  

     
     Pediatric Radiology CasesLiterature:

    5. Medline: Medline
    K. Bohndorf, H. Imhof
    "Radiologische Diagnostik der Knochen und Gelenke"
    Georg-Thieme-Verlag 1998  

     
     Pediatric Radiology CasesKeywords:

    fibrotic corticalis defect, fibrous cortical defect, fibrotic, corticalis defect, non-ossifying, fibroma, fibula, fibrous metaphyseal defect, non ossifying fibroma  

     
     Pediatric Radiology Cases Cite this article:

    H Frimmel. Fibrous cortical defect. PedRad [serial online] vol 2, no. 8.
    URL: www.PedRad.info/?search=20020815173954  

     
     Pediatric Radiology Cases Read similar articles: non ossifying fibroma&type=1-17">corresponding keywords
    in the same field:
    or in the region:
    or in the tissue/organ:
    or with the etiology:
     
     Pediatric Radiology CasesImages to this case: There are X-Ray-images available for this case. [ X-Ray ] There are MRI-images available for this case. [ MRI ] View all modalities [ All ]   
     
    Fibrous cortical defect
    ( This case will be soon translated into the english language. )
    H Frimmel. Fibrous cortical defect. PedRad [serial online] vol 2, no. 8.
    URL: www.PedRad.info/?search=20020815173954


     

    Search similar cases in:
    More links about this topic on Pubmed  More links about this topic on Yahoo  More links about this topic on Altavista  More links about this topic on MSN  More links about this topic on Google  More links about this topic on Fireball

    Peer-reviewed Radiology Search



    Fibrous cortical defect
    Other cases by these authors:

    Search T.Haufe in Medline T.Haufe (1)   
    • 1:
    Search Radiologie in Medline Radiologie (10)   
    Search SKH Dresden-Neustadt in Medline SKH Dresden-Neustadt (1)   
    • 1:
    Search Dirk Schaper in Medline Dirk Schaper (59)   
    Search V. Hofmann in Medline V. Hofmann (17)   
    Search H. Frimmel in Medline H. Frimmel (23)   

    Fibrous cortical defect  
     
    Fibrous cortical defect
    ( This case will be soon translated into the english language. )
    H Frimmel. Fibrous cortical defect. PedRad [serial online] vol 2, no. 8.
    URL: www.PedRad.info/?search=20020815173954


     

    Which diagnosis have other collegues guessed?


    • Testicular microlithiasis
      Votes: 17 (60 %)


    • Orchitis
      Votes: 3 (10 %)


    • Leukemic testicular infestation
      Votes: 3 (10 %)


    • Disseminated Sartoli-cell tumor.
      Votes: 5 (17 %)



        Total answers: 28

     
    Fibrous cortical defect
    ( This case will be soon translated into the english language. )
    H Frimmel. Fibrous cortical defect. PedRad [serial online] vol 2, no. 8.
    URL: www.PedRad.info/?search=20020815173954


     

    Medical Dictionary
    Search in medical dictionary for
    Or type in a keyword
    ( Provided by The On-Line Medical Dictionary )




    1 = less interesting)
     
    Fibrous cortical defect
    ( This case will be soon translated into the english language. )
    H Frimmel. Fibrous cortical defect. PedRad [serial online] vol 2, no. 8.
    URL: www.PedRad.info/?search=20020815173954


     




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