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Thalassemia intermedia
M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
URL: www.PedRad.info/?search=20020126181655
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 | Images to this case: |  [ X-Ray ]  [ All ] | |
| | Author/s: | M. Paetzel (Cleveland/USA) | |
| | Email Address: | Viewable for logged on visitors (Log on) | |
| | Age: | 9 Years | |
| | Gender: | Female | |
| | Region-Organ: | Head-Bones | |
| | Most likely etiology: | congenital | |
| | History: | 9 year old girl, paleness, hepatosplenomegaly | |
| | Pathomorphology or Pathophysiology of this disease : | Autosomal hereditary hemoglobin defect with a resulting hypocromatic, microcytic anemia. Through hemolysis is an iron overload common. Extensive medullary and extramedullary bleeding. | |
| | Radiological findings: |
 <- view X-Ray 1
X-Ray 1: Lateral View
 <- view X-Ray 2
X-Ray 2: Cranium (extensive): Macrocephaly with widend diploe, thinned tabula externa and subperiostal spiculae. Holes in the tablua externa re possible.
 <- view X-Ray 3
X-Ray 3: Hand: Trabelces are affected in the metacarpals. Widening of the bone marrow and thinning of the cortical zone through the hypertophied blood-producing marrow..
Further typical changes of the increased erythropoeisis is seen in the ribs, facial skeleton and in the vertebral bodies are possible not shown.
In the MRI (T2): Signal reduction in bone marrow, in the liver and in the spleen (iron deposition).
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| | Diagnosis confirmation: | Genetics | |
| | Which DD would be also possible with the radiological findings: | Other hemolytic anemias (spherocytosis, enzyme defects) | |
| | Course / Prognosis / Frequency / Other : | N/A | |
| | Comments of the author about the case: | N/A | |
| | First description / History: | N/A | |
| | Literature: | N/A | |
| | Keywords: | Paleness, hepatosplenomegaly, autosomal, hemoglobin defect, microcytic, anemia, Thalassemia intermedia, child, childhood, pediatric radiology | |
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Cite this article: |
M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
URL: www.PedRad.info/?search=20020126181655 |
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Read similar articles: |
with corresponding keywords
in the same field: Head-Bones
or in the region: Head
or in the tissue/organ: Bones
or with the etiology: congenital
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| | Images to this case: | [ X-Ray ] [ All ] | |
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Thalassemia intermedia
M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
URL: www.PedRad.info/?search=20020126181655
| |
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Thalassemia intermedia
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Thalassemia intermedia
M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
URL: www.PedRad.info/?search=20020126181655
| |
| |
Thalassemia intermedia
M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
URL: www.PedRad.info/?search=20020126181655
| |
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Thalassemia intermedia
M Paetzel. Thalassemia intermedia. PedRad [serial online] vol 2, no. 1.
URL: www.PedRad.info/?search=20020126181655
| |
